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doi: 10.3389/fonc.2022.874645

Symptoms are predominantly linked to the affected areas, presenting as liver-related issues such as vomiting, yellowish skin discoloration, and leg swelling, or neurological symptoms like tremors, speech difficulties, personality alterations, and auditory or visual hallucinations [121]

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Ambarus CA, Noordenbos T, de Hair MJ, Tak PP, Baeten DL

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Of Navitoclax In Combination With Ruxolitinib Versus Ruxolitinib In Subjects With Myelofibrosis (TRANSFORM-1)

These findings suggest that TGF1 inhibits PDH and -KGDH by reducing the acetylation of the common E3 enzyme DLD at K430, and the TGF1-DLD-K430ac axis correlates with the clinicopathological features of GC