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This dual mechanism has made Tirzepatide a key compound in metabolic and glucose-regulation research

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Studies suggest that various molecular pathways are involved in IC/BPS, including the JUN N-terminal kinase (JNK) pathway, transient receptor potential (TRP) channels, activated mast cells, mucosal signalling, circadian rhythm regulation, inflammation and neural dysregulation

However, in Adipor1 / mice, the function of P5 was completely abolished, further supporting the notion that P5 function relies on AdipoR1