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The mechanisms by which PPAR loss leads to aberrant apoptosis and reduced cell survival have been associated to altered lipid metabolism and accumulation of stress and pro-inflammatory molecules such as reactive lipids and ROS deriving from the 5-LO and COX2 pathways, that specifically activate a lipid-mediated programmed cell death [33]

-agonists, a class of phenylethanolamine compounds similar in chemical structures, are widely used for the treatment of respiratory diseases in clinical applications 4, 5

1 2 "Effective dosing of -carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis"

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Lord C, Rutter M, Le Couteur A (1994) Autism diagnostic nterview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders