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Physiology-Lung Cell

Seeringer A, Kirchheiner J

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Dopaminergic neurons are especially prone to ferroptotic damage, partly because dopamine metabolism itself can generate reactive quinone species, contributing to oxidative stress

It is also involved (as a cofactor of the enzyme dihydroorate dehydrogenase) in the metabolism of pyrimidines, fatty acids and mitochondrial uncoupling proteins, as well as in the regulation of the mitochondrial permeability transition pore [1]

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