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This may result from concentration errors, pH changes, or degradation

The effect of dietary modification on the training outcome and body composition in patients undergoing a cardiac rehabilitation programme

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Regulation of the arginine/NO pathway is paramount: while endothelial NO synthase (eNOS)-derived NO sustains cerebral blood flow by vasodilation, iNOS in activated glia overproduces NO, spawning neurotoxic peroxynitrite that exacerbates lipid peroxidation and mitochondrial dysfunction [201]

Milani D, Athiyah U, Hariyadi DM, Pathak YV: Surface Modifications of Liposomes for Drug Targeting

PT-141 changed that by introducing a different entry point: the central nervous system
