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13 In 1993, The Journal of Clinical Apheresis published a paper detailing the use of TPE as either a first- or second-line therapy to be used with other modalities on disorders such as Raynauds disease, systemic lupus erythematosus, coagulation factor inhibitors, familial hypercholesterolemia, acute Guillain-Barr syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, cryoglobulinemia, Goodpastures syndrome, and thrombotic thrombocytopenic purpura

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Synapse 15 , 243245 (1993)

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Despite its excellent record to date, researchers administering epithalon injections should note the risk of side effects like injection site inflammation, itching, swelling, or pain

Moretti R, Peinkhofer C