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This raises the possibility that GPX3 might protect interstitial fibrotic ECM from oxidative damage with a potential impact on the resolvability of fibrotic matrix

However, when this shield is overwhelmed due to an overproduction of free radicals or a failure of the antioxidant system, the redox balance shifts, resulting in a state of oxidative stress

Key regulators of ferroptosis are also directly degraded by the lysosome

Lamolet B, Pulichino AM, Lamonerie T, Gauthier Y, Brue T, Enjalbert A et al (2001)

Spine 26(6): E139-E142, Mar 2001
