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Autophagy in oxidative cell death Autophagy is a cellular recycling system that is pivotal for breaking down and removing damaged or unnecessary proteins, organelles, and cellular debris

Electrophilic inhibitors of Keap1 have side effects due to off-target effects, and the resulting PPI inhibitors have been extensively studied and have broad clinical potential

doi: 10.1371/journal.pone.0045357

Septic cardiomyopathy (SIC) In a model of LPS-mediated septic cardiomyopathy, some researchers revealed that LPS caused ferroptosis and septic cardiac injury by downregulating GPX4 protein levels and increasing COX-2 [93]

Linus Pauling Institute Oregon State University Updated in November 2004 by: Jane Higdon, Ph.D