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10 June 2019

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doi:10.1016/S0969-2126(98)00073-2

Le, MD The information presented in this article is for educational and research purposes only, intended for laboratory professionals, researchers and collaborators

Is AOD 9604 safe for patients with diabetes or insulin resistance

Key Highlights AOD9604 activates lipolytic pathways through beta-3 adrenergic receptor upregulation and cAMP-PKA-HSL cascade activation in adipocytes The peptide inhibits acetyl-CoA carboxylase to suppress lipogenesis while promoting fatty acid oxidation in laboratory models Research confirms no IGF-1 stimulation or glucose metabolism disruption, distinguishing it from full-length growth hormone Cartilage studies show proteoglycan synthesis enhancement and improved tissue structure in osteoarthritis animal models What is AOD9604