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In fact, metformin shows such great promise as an anti-aging drug (Martin-Montalvo 2013

They aren't supplying B12 for any medical condition, so they don't have to worry about what they sell going off

Metformin (for diabetes), proton pump inhibitors (such as omeprazole or esomeprazole), and H2 blockers (such as famotidine) can all reduce B12 absorption over time

They're essentially unreported in the community

nausea and vomiting are the top reasons for discontinuation in clinical trials BPC-157 has demonstrated gastroprotective effects across multiple animal models through three proposed mechanisms: FAK-paxillin mucosal repair, dopaminergic anti-nausea pathways, and vascular support for mucosal perfusion Community co-administration of BPC-157 with semaglutide and tirzepatide is widespread, but no human clinical trial data exists for this combination The Thetis Phase 3 trial (n=280) confirms that pharmaceutical-grade GLP-1 GI side effect management is an active research priority though it does not study BPC-157 specifically Without a structured log of your GI baseline, you cannot evaluate whether any protocol change is actually working Sources Wilding JPH et al

The compound's effects on muscle stem cell rejuvenation particularly highlight its anti-aging potential