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Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency

However, there may be other causes why some people with B12 deficiency require more frequent injections

It counteracted free radical formation regardless of the effect on NO, whether an increase or decrease [80,144,175,181,182,192,193,194,195,196,197]

In contrast, some specific assays using non-dividing cells require higher seeding densities, thereby changing the ratio between the number of particles and exposed cells

Clin Gastroenterol Hepatol 4:387394

Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2