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In addition, tetrahedral framework nucleic acids have been developed to directly neutralize A toxicity and restore synaptic integrity (122)

Since the pKa of Sec is ~ 5.2, the selenol (RSeH) of Sec exits in selenolate (RSe ) form under the physiological condition [8, 11,12,13,14,15,16,17,18]

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[Google Scholar] 142.Criado JJ, Fernndez ER, Manzano JL, Alonso A, Barrena S, Medarde M, Pelaez R, Tabernero MD, Orfao A