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L-acetylcarnitine in dysthymic disorder in elderly patients: a double-blind, multicenter, controlled randomized study vs

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LDE has been frequently associated with gold, antimalarials, antihypertensives, NSAIDs, proton-pump inhibitors, anti-diabetics, anti-tuberculars, TNF- inhibitors, tyrosine kinase inhibitors, checkpoint inhibitors, and biological agents.[6,7,8] Although the mechanism of LDE is not fully understood, it has been hypothesized that cross-reactivity between the drug and keratinocytes both acting as antigens, leading to T cell-mediated autoimmune damage of basal keratinocytes