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Am J Clin Nutr 108:612

several studies support a causal relationship between augmented NNMT activity in cancer cells and tumor proliferation/progression in a variety of cancerous states with potential implications for NNMT as a biomarker for cancer prognosis and a relevant target for anti-cancer therapeutic development

doi: 10.1158/1078-0432.CCR-11-3114

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Elevated cAMP activates protein kinase A (PKA), which then phosphorylates and activates hormone-sensitive lipase