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For instance, hypoxia induces extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation to activate HIF-1, which directly binds to the promoter of ABCG2 gene and subsequently enhances ABCG2 transcription, leading to gemcitabine chemoresistance in pancreatic cancer cells (He et al., 2016)

Various modifications can be employed for actively charging the liposomes, including immunoglobulin, carbohydrate, peptide, aptamer, protein, PEG, and small molecules such as folic acid and transferrin [112]

Thyroid ultrasound

Available at SSRN: 10.2139/ssrn.3569838 [DOI] [Google Scholar] 27.Qin C, Zhou L, Hu Z, et al

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