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Taking disulfiram and metronidazole together can cause throbbing headaches, flushing, thirst, sweating, difficulty breathing, chest pain, heart palpitations, rapid or irregular heartbeat, low blood pressure, lightheadedness, dizziness, blurred vision, nausea, vomiting, and confusion

High doses might also possibly interfere with levels of other vitamins, enzymes and minerals, which is always a potential problem when taking any nutrient in very large quantities

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It is recommended to take the tablets at a fixed time every day to establish a routine and improve the stability of efficacy