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Delmonte J, Kantarjian H, Andreeff M, Faderl S, Wright J, Zhang W, Konopleva M, Verstovsek S, Borthakur G , Ravandi F, Cortes J

Drug Tolerance with repeated use has been reported, and most likely results from down-regulation and/or internalization of alpha receptors

Note that the treatment protocol of 3 days of treatment followed by 11 days off is much lower than that recommended in the Physician Desk Reference for moderate/severe lead poisoning (21 days of continuous treatment), so it is expected that the treatment regimen used in this study would have fewer side-effects than for a 21-day treatment regimen

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The recombinant mutants K26A and D90A were subsequently purified (Supplementary Fig

Intl J Immunopathol and Pharmacol 4:19-32, 1991