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SOD2 (known as manganese SOD, MnSOD) localizes to the mitochondrial matrix, while SOD3 is found in the extracellular matrix

[DOI] [PMC free article] [PubMed] [Google Scholar] 216.Colca J.R

heterogeneity within brain endothelial and perivascular cell types

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Internal validity refers to the degree to which a study accurately establishes a cause-and-effect relationship, free from systematic error

In the cytosol, a minor contribution to acetate production arises from endogenous generation via histone deacetylation 251 , whereas a more substantial intramitochondrial source is from pyruvate 169,170,252,253