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Safety Prior to randomization, one patient (of 224 enrolled participants) died, with no relationship between the death and the study or the supplement identified by the CIMATEC committee, since the death occurred prior to collect blood samples or consume the investigational supplement

The significance of these findings in humans is unknown
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Gender Differences in Prevalence and Patterns of Dietary Supplement Use in Elite Athletes

A handful of case reports describe efficacy from naloxone in mild-moderate intoxications (table below)

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