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Mitochondrial dysfunction in aging: much progress but many unresolved questions
In combination with other data that suggests arrestin-3 recruitment can reduce dependence [14, 45, 57], abuse liability and relapse [15], these findings indicate that new opioid development efforts should focus on identifying compounds that signal with a profile mimicking that of endogenous ligands, which engage both G protein and arrestin-3
39 GuoJ.XuB.HanQ.ZhouH.XiaY.GongC.et al (2018)
