acetaminophen glutathione depletion hek cells The Metabolism of and the Synthesis of Downregulation of Glutathione-Mediated Detoxification Capacity
Description
Lysosomes constitute a major reservoir of cellular cyst(e)ine (Abu-Remaileh et al., 2017), incorporating roughly half of newly synthesized cysteine despite comprising only 4% of cell volume (Pisoni et al., 1990), and oxidative cues such as HO can mobilize this pool for GSH biosynthesis (He et al., 2023)

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