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Exercise and Physical Performance Research Age-Related Physical Decline Investigations in aging mice demonstrated that MOTS-c treatment significantly improved physical capacity across multiple age groups: Enhanced running endurance in young (2-month), middle-aged (12-month), and old (22-month) mice Improved grip strength and rotarod performance in aged animals Late-life intermittent treatment (beginning at 23.5 months) increased healthspan metrics Reversal of age-dependent decline in mitochondrial function Notably, human studies confirmed that exercise induces endogenous MOTS-c expression in both skeletal muscle tissue and circulation, suggesting evolutionary conservation of exercise-responsive signaling

187 This degradation results in DNA damage, potentially contributing to hepatocarcinogenesis, particularly in hepatocellular tumors with high NO synthase and low GSNOR levels

They connect information across functions and keep the process moving under tight timelines

doi: 10.3389/fnut.2023.1214734

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