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The glucose metabolism capacity decreases in diabetic patients, which causes the ulcer wound to be in a state of hyperglycemia, and further leads to impaired angiogenesis and delayed wound healing in diabetes (Hajmousa et al., 2018)

The entire injection process can take between 10 and 45 minutes, depending on the complexity and number of syringes used

And in 10 of 12 studies assessing acceptability, over 75 percent rated the pen as more acceptable than the traditional approach

[7, 8] Efficiently delivering three modalities simultaneously may improve performance and recovery to a greater extent than any single one, while maintaining the treatment time of a single therapy

Sharma et al., 2015

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Seitz G., Bonin M., Fuchs J., Poths S., Ruck P., Warmann S.W., Armeanu-Ebinger S