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Studies in animal models suggest that vulnerability to relapse reflects an alteration in glutamate homeostasis in the nucleus accumbens [114, 116]

Researchers have discovered a potent and selective glutamine transporter inhibitor, V9302, which specifically targets the SLC1A5 and effectively inhibits glutamine uptake [191].SLC1A5 has been reported to be involved in the modulation of the immune microenvironment in multiple types of tumors

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Additionally, Gammaproteobacteria, recognized as opportunistic pathogens, increases susceptibility to intestinal infections and exacerbate inflammation-driven metabolic dysfunction, impairing thyroid hormone utilization (Yao et al., 2020)

This suggests that these hormones have pleiotropic effects beyond lowering blood glucose levels [9,10,11]

Brain Res Mol Brain Res 1997
