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Not inherently, but misuse or high stimulant content can cause side effects

Since a link between infections and autoimmune diseases has been well established, this correlation could explain the presence of autoimmune symptoms in ME/CFS (487)

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[Google Scholar] Farvid M.S., Sidahmed E., Spence N.D., Mante Angua K., Rosner B.A., Barnett J.B

Furthermore, it was observed that PBM increased the expression of cellcell junction proteins (ZO-1 and VE-cadherin) in endothelial cells thereby indicating improved vascular integrity

Silva AR, Bernardo A, Costa J, Cardoso A, Santos P, de Mesquita MF, Vaz Patto J, Moreira P, Silva ML, Padro P