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Therefore, a study used dual molecules such as ciprofloxacin (CIP) and an efflux inhibitor 5-Nitro-2-(3-phenylpropoxy) pyridine (5-NPPP) were used to synthesize and deliver together with an antibiotic can re-sensitize pathogen against antibiotics and simultaneously treat the infections

[DOI] [PMC free article] [PubMed] [Google Scholar] 61.Aldeyra Therapeutics clinical trial information

Titles of the papers were shortlisted and very old papers were avoided with the exception of whether they were pioneer work or whether they imparted important information on the chemical and biochemical domain of As

Andreeff M , Kempin S, Arlin Z, Mertelsmann R, Espiritu E, Gee T

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It is localized to the mitochondria and showed non-substrate behavior for major CYP450 isoforms (2C9, 2D6, 3A4), along with no inhibitory effects against CYP1A2, 2C9, 2D6, 2C19, and 3A4, suggesting a low risk of metabolic interactions