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DMF induces the expression of L-2-hydroxyglutarate dehydrogenase (L2HGDH) to downregulate L-2-hydroxyglutarate (L2HG) and increase global and locus-specific DNA hydroxymethylation levels

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doi: 10.1016/j.archger.2010.10.004

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Because it is used up quickly during times of stress, illness, or toxin exposure, many people find that their natural production cannot keep up with the body's demands