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ROS can be categorized into two types: FRs and nonradicals

Science (1992) 256(5064):167780.10.1126/science.256.5064.1677 46 RowlinsonSWBehnckenSNRowlandJEClarksonRWStrasburgerCJWuZet alActivation of chimeric and full-length growth hormone receptors by growth hormone receptor monoclonal antibodies

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The peroxidation of cell membrane lipids, triggered by iron and the inactivation of antioxidant pathways, results in the accumulation of lipid peroxides and reactive oxygen species (ROS), causing cell membrane rupture and cell death
