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A hydrophobic portion of the tag itself increases the solubility of the fusion G protein, and it has been shown that no structure or activation dynamics are altered during the purification process using the Profinity eXact system (Abdulaev et al., 2005)

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Korean J Physiol Pharmacol (2014) 18(5):397402.10.4196/kjpp.2014.18.5.397 63 KimJ-SRyuS-YYunIKimW-JLeeK-SParkJ-Wet al1alpha,25-Dihydroxyvitamin D(3) protects dopaminergic neurons in rodent models of Parkinsons disease through inhibition of microglial activation