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Combination therapies that engage complementary mechanisms of action offer a rational strategy to enhance efficacy while minimizing toxicity
PannerchelvanSRios-SolisLWasohHSobriMZMWongFWFMohamedMSet al

228,229 Genetic studies suggest that polymorphisms in the aldose reductase gene influence individual susceptibility to DPN, 230 highlighting the potential for personalized therapies

Meta-analysis of the relationship between CXCR4 expression and metastasis in prostate Cancer

PLoS One 8:e70833

434 Patients with PDPN have increased epineurial blood flow and intravascular oxygen saturation, perhaps secondary to arteriovenous shunting due to sympathetic denervation