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In most T1D patients the administration of insulin can lead to severe hypoglycemia as a result of these altered responses of -cells to hypoglycemia
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This review summarizes our current understanding of how changes in intra-portal insulin delivery to the liver in health, disease states and drug therapy use and misuse that leads to alterations in GH/IGF-I secretion that may dictate management decisions in afflicted patients
it occurs in approximately 1 out every 700800 live births [60]
