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Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation

2004J Neurosurg

Raju, G

10.1016/j.heliyon.2024.e28459 65 LadeS.AlokS.NagdevS.GolaniP.AgrawalA.KoseyS

However, it is clear that significant uncertainties arise from using animal data in the prediction of human toxicity responses due to anatomical, physiological, and biochemical differences between rodent and human respiratory systems and differences in breathing patterns ( In this context, recent research anchored in human-relevant science has focused on developing human-relevant in silico and in vitro tools and approaches (New Approach Methodologies, NAMs) that can be employed, together with existing information, within the next-generation risk assessment (NGRA) of materials to assess the risk of lung toxicity (OECD, 2022

Research shows that understanding the differences between these compounds will help scientists design better studies and improve content in metabolic research