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The diverse forms of regulated necrosis may be interrelated, share molecular pathways and cell defence mechanisms and coexist in the same kidney disease, affecting different cell types or the same cell type synchronously or sequentially

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The mechanism for this was related mainly to the effect of fiber on gut microbiota, which tends to regulate the hormones and fight against inflammation [126]

Collectively, these systems exemplify how SEDDSs/SMEDDSs enable multifaceted urate control through bioavailability optimization and pathophysiological targeting, offering superior efficacy-to-safety ratios compared to conventional formulations

Consequently, these activated nanoparticles can catalyze the generation of antibacterial species precisely at the site of Helicobacter pylori infection, enabling targeted bacterial eradication and biofilm disruption without inducing antibiotic resistance