glutathione colon cancer DLAT sustains redox homeostasis and prevent colorectal from ferroptosis by regulating SLC25A39-mediated mitochondrial transport JCI - PKLR promotes colorectal

However, some possible adverse reactions can occur

383 Moreover, we also found that bromodomain containing 4 (BRD4) is upregulated in ICB-resistant melanoma patients, and inhibiting BRD4/AKR1C2 axis by bromodomain and extra-terminal motif (BET) inhibitors has been shown to enhance the susceptibility of melanoma to ferroptosis and immunotherapy

Protein extraction and immunoblot analysis

After its synthesis, GSH is delivered to other intracellular compartments, including mitochondria, endoplasmic reticulum, nucleus, and to the extracellular space (e.g., blood plasma and bile) for utilization by other cells and tissues (Figure 1B)

Wu, L., Zhang, H., Xu, C

10.1016/S0002-8703(99)70250-4 32