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This evidence necessitates a paradigm shift from a one-size-fits-all supplementation approach to a genotype-stratified strategy, wherein GST status could be used to identify individuals most likely to benefit from SFN-based prevention

Redox-responsive chitosan hydrogel releases mitochondria-targeted fullerenol to reprogram M1/M2 macrophage balance for diabetic wound healing

27 , 28 (Figure 2)

For instance, targeting the RNF217-mediated degradation pathway of FPN could help preserve its function, thereby reducing intracellular iron accumulation and the risk of ferroptosis

Endovascular perforation murine model of subarachnoid hemorrhage

Stalk cells follow the tip cells and branch out from the parent vessel, establishing the vascular lumen and junctional connections to the forming sprout