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Deficiency has a measurable effect on both, particularly under physical stress

Because fasted-state absorption allows the peptide to bind NNMT enzymes without interference from competing substrates in the gut
[DOI] [PubMed] [Google Scholar] 50.Kang E.A., Han Y.M., An J.M., Park Y.J., Sikiric P., Kim D.H., Kwon K.A., Kim Y.J., Yang D., Tchah H., et al

STEP 5: long-term data The 2-year STEP 5 trial provides the most important real-world context

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Obeid R, Herrmann W
