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Previous studies have shown that D4/H56 in Lm PC-PLC could be replaced by Bc PC-PLC sequence with no harm to enzymatic activity 26,65

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Preliminary results indicate a significant improvement in neurological outcomes (improved NCV and reversal of painful symptoms) in a small group of gabapentin-treated CIPN patients (Aghili et al., 2019), despite the fact that the neuroprotective effect remains to be determined by using a larger cohort of patients (Pandey et al., 2023)