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People might choose B12 shots over oral supplements for several reasons: Increased Absorption: Injections bypass the digestive system, providing direct delivery of vitamin B12 into the bloodstream

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Loss of synaptic connections is a major cause of neuronal apoptosis and discourages neurogenesis

Inflammation Induction of inflammatory responses in the glomerulus, renal tubular cells, and the surrounding interstitium is another mechanism of drug-induced nephrotoxicity that can lead to fibrosis and renal scarring (Naughton 2008b)

Some genetic diseases that involve defects of transcobalamin, methylmalonyl CoA mutase, or enzymes in the pathway of cobalamin adenosylation, may also result in vitamin B12 deficiency (IOM, 2000)

However, completions continue to lag