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Homocysteine in the body is recycled to form methionine or converted to cysteine with the assistance of vitamins B6, B12, and folate (Silla et al

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Glutamine can also be oxidised in the TCA cycle as an energy source, serve as a substrate for nucleotide synthesis, NAD + and NADPH synthesis (Reference Curi, Newsholme and Marzuca-Nassr3,Reference Cruzat, Macedo Rogero and Noel Keane4)

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46 Disruptions in these pathways can lead to protein misfolding and accumulation, triggering ER stress and the unfolded protein response (UPR), thereby inducing cancer