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Clinical evidence indicates that children with type 1 DM (T1DM) exhibit reduced levels of branched-chain amino acids (BCAAs) and decreased Fischer ratios (BCAA/AAA (aromatic amino acid)) (Hassan et al., 2023)

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In this equation, is the ratio of the solute's radius to the pore radius p is the particle porosity, is the tortuosity factor, is the distribution coefficient for the solute, and is the diffusion coefficient for the solute in free solution