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B6 also plays an important role in immune functions and is also a bio-marker of inflammation with its down-regulation being associated with severe inflammation (16)

Another autoantibody found in 10% to 15% of patients with stiff-person syndrome is against glycine-a1 receptor (anti-GlyR) (52)

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Given that EtOH-induced mitochondrial dysfunction and ER stress are intimately involved in the pathogenesis of ALD, future studies to examine these pathways under the current experimental setting will provide important mechanistic information underlying the protection seen in GCLM KO mice

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This comprehensive review elucidates the pathogenic mechanisms and identifies potential preventive targets for PCOS, thereby establishing a scientific foundation for developing effective treatment strategies