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Proc Natl Acad Sci USA (2013) 110(35):1433641

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Key considerations for B12 intravenous dosing include: Initial dose: 1,000 mcg per infusion Frequency of administration: varies based on clinical need Monitoring of patient response to adjust dosing as necessary IV Infusion Methods and Duration B12 IV infusions are given slowly to avoid side effects

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Hyperhomocysteinemia results from an inhibition of the remethylation pathway or from an inhibition or a saturation of the transsulfuration pathway of homocysteine metabolism