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Taken together, the isotope labelling experiments prove that lysine degradation as depicted in Fig

Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation

Fundamentally, all of these conditions can be at least partially attributed to the dysfunction and failure of mitochondria in different highly metabolic tissues

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Whitehead M, Osborne A, Widdowson PS et al (2019) Angiopoietins in diabetic retinopathy: current understanding and therapeutic potential