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In CC531, a colon cancer cell line, GT was upregulated in a time and dose-dependent manner to irradiation

According to estimates, up to 15% of the general population may be vitamin B12 deficient

Finally, vitamin B12 is crucial for the biochemistry of the nervous system, participating in DNA synthesis, methionine synthesis, methylation reactions, myelin synthesis, and neurotransmitter production (, , , , , , )

Mutations or aberrant expression of URs have been reported to cause widespread changes in the expression of their downstream target genes, thereby contributing to disease pathogenesis 19,20,21,22,23

While most of the cysteine for glutathione was derived from exogenous source in nutrient replete culture, serine-derived cysteine may become more important under nutrient-limiting conditions