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Disruption of this community-marked by reduced Lactobacilli abundance and increased microbial diversity-has been associated with inflammation and a heightened risk of persistent HPV infection, ultimately contributing to the development of cervical lesions

Additionally, the expression of ferritin heavy polypeptide 1 (FTH1), an iron-storage protein, decreases, while the tumor suppressor gene p53 accelerates ferroptosis by transcriptionally inhibiting SLC7A11 expression (Yang et al., 2022)

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[DOI] [PubMed] [Google Scholar] 274.Budhdeo S, de Paiva ARB, Wade C, Lopes LCG, Della-Ripa B, Davagnanam I, Lucato L, Mummery CJ, Kok F, Houlden H, Werring DJ, Lynch DS