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Using selected doses and time point for ASA toxicity, we have demonstrated that when GSH synthesis is inhibited in HepG2 cells by buthionine sulfoximine (BSO), prior to ASA treatment, cytotoxicity of the drug is augmented

A naturally occurring copper-binding tripeptide found in human plasma, notable for its genomic reach modulating approximately 4,000 human genes involved in tissue remodeling, growth factor expression, and anti-aging responses.