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57 Positive effects of B12 on homocysteine levels have also been observed in other patient populations, including healthy adults, 46 vegetarian women, 58 generally healthy women, 59 older adults with elevated MMA and homocysteine, 37 and patients with type 2 diabetes mellitus

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Therefore, it is plausible that inhibiting FAox when TCA activity is already low and GSSG already high has no further effect, potentially explaining why fibroblasts are refractory to protection by ET

GHK-Cu timing matters less for systemic effects, though evening administration may support overnight regenerative processes