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p = 0.0318), which were maintained after a 12-week washout [32]
Patients often report initial gastrointestinal side effects, such as nausea and vomiting, which can be distressing and sometimes lead to discontinuation of the drug

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Patients experiencing nausea should be advised to: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods that may exacerbate nausea Stay well-hydrated with small, frequent sips of water Consider bland foods such as crackers, toast, or rice during symptomatic periods Avoid lying down immediately after eating For constipation , increasing dietary fibre intake through fruits, vegetables, and whole grains, alongside adequate fluid consumption (1.5-2 litres daily), often provides relief

Clinical Nutrition Open Science 2023