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Additionally, anti-nuclear IgG4 antibody significant titers have been detected in SLE patients, and it has been suggested that the effect of these antibodies on complement consumption and the production of proinflammatory cytokines may play a role in inhibiting the progression of SLE

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doi: 10.1007/s12038-010-0004-8

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Choosing the right needle size depends on factors such as gauge, length, and injection technique