glutathione s transferase review article The Multifaceted Role of S-Transferases in Health and Disease Frontiers | Glutathione S-Transferases: Role

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In the prevalent non-amyloidogenic pathway, APP is cleaved by the membrane-bound enzyme -secretase [125] within its A domain, resulting in the formation of extracellular secretion of neuroprotective soluble APP (sAPP) fragments [126] and short a membrane-bound C-terminal fragment (CTF or -CTF or C83) followed by -secretase cleavage of C83 to form a 3 kDa peptide (p3) with release of the APP intracellular domain (AICD) into the cytoplasm [127, 128]

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Induction of NQO1 by SFN also coordinately induces [58] genes encoding cellular NADPH-regenerating enzymes such as glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and malic enzyme

Finally, the eighth set of results is the parameter sensitivity analysis, in Section 3.5, which provides a detailed understanding of which parameters are most sensitive to variations in the integrative computation of oxidative stress and C1 metabolism